Foot Cream A Potential HIV Cure?
A very common anti-fungal drug prescribed to combat toe fungus has been shown in cultures to kill HIV dead. But here's the kicker: unlike anti-virals, HIV doesn't return after use of the medication has been stopped.
In a study performed at Rutgers New Jersey Medical School, not only does the drug Ciclopirox completely eradicate infectious HIV from cell cultures, but unlike today's most cutting-edge antiviral treatments, the virus doesn't bounce back when the drug is withheld. This means it may not require a lifetime of use to keep HIV at bay.
The same group of researchers had previously shown that Ciclopirox -- approved by the FDA and Europe's EMA as safe for human use to treat foot fungus -- inhibits the expression of HIV genesin culture. Now they have found that it also blocks the essential function of the mitochondria, which results in the reactivation of the cell's suicide pathway, all while sparing the healthy cells.
The researchers said that one aspect of HIV that makes it particularly persistent, even in the face of strong antiviral treatments, is its ability to disable a cell's altruistic suicide pathway -- which is typically activated when a cell is damaged or infected. In other words, infected cells that would normally commit suicide to spare healthy cells no longer pull any altruistic kamikaze missions. Ciclopirox tricks these cells back into their old ways with a double negative, disabling the disabling of the suicide pathway.
A few commenters have been critical of the potential use to eradicate HIV, claiming that Ciclopirox's topical effects will be unsuccessful in the blood stream.
What do you think of this potential way to combat the disease?