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Researchers Successfully Eliminate HIV Virus From Human Cells

A team of researchers at the Temple University School of Medicine led by Dr. Kamel Khalili and Dr. Wenhui Hu, have successfully designed a way to "snip" HIV-1 genes from human cells, leaving the cells completely HIV free! 

 

From the Temple University School of Medicine:

In a study published July 21 by the Proceedings of the National Academy of Sciences, Dr. Khalili and colleagues detail how they created molecular tools to delete the HIV-1 proviral DNA. When deployed, a combination of a DNA-snipping enzyme called a nuclease and a targeting strand of RNA called a guide RNA (gRNA) hunt down the viral genome and excise the HIV-1 DNA. From there, the cell's gene repair machinery takes over, soldering the loose ends of the genome back together – resulting in virus-free cells.

 

"Since HIV-1 is never cleared by the immune system, removal of the virus is required in order to cure the disease," said Dr. Khalili, whose research focuses on the neuropathogenesis of viral infections. The same technique could theoretically be used against a variety of viruses, he said.

 

The research shows that these molecular tools also hold promise as a therapeutic vaccine; cells armed with the nuclease-RNA combination proved impervious to HIV infection.

Dr. Khalili went on to explain the challenges that remain:

The HIV-1 eradication approach faces several significant challenges before the technique is ready for patients, Dr. Khalili said. The researchers must devise a method to deliver the therapeutic agent to every single infected cell. Finally, because HIV-1 is prone to mutations, treatment may need to be individualized for each patient's unique viral sequences.

 

"We are working on a number of strategies so we can take the construct into preclinical studies," Dr. Khalili said. "We want to eradicate every single copy of HIV-1 from the patient. That will cure AIDS. I think this technology is the way we can do it."

Exciting progress!

 

Hopefully Dr. Khalili and Dr. Hu will have the appropriate resources to continue making the breakthroughs that can lead to a cure for HIV and AIDS! 

 

 

(H/T: Towleroad)

 

Comments

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Hello my good friends please do not see this strange cause it my life story about my healing, i was having HIV for good 6yrs. Things were not working fine for me due to my health status i know longer have friends know lover it even takes time before my family co-operate with me due to this i tried all possible means i can to get this devilish sickness out of my body i went to hospitals hierarchies and other heath organization but all remains the same still yet i never gave up cos i was not born with this illness so i decided to take it over to the internet to see if i could get remedy, on my search i saw a testimony of a woman, she said she was also having a terrible sickness for over 3yrs but now she is healed i was surprise at first when i saw her test so she wrote a name dr AZIEGBE and also gave his email id so i mailed them which is (DRAZIEGBEHERBALHOMEOFSOLUTION@gmail.com) i told him about my problem and after the processes he told me that am healed but i never believed he told me to go and confirm it from the hospital were i have been taking treatment still i never believed also although he gave me evidence that the sickness was gone. Finally i decided to go for check up and to my surprise my doctor said the sickness was know longer there with thought of joy i started shearing tears. My friends, today am now married bless with 2kids, so if you have any sickness kindly email (DRAZIEGBEHERHBALHOMEOFSOLUTION@gmail.com) or call him +2348173547483 sir i will forever remain in you debt. Thank you sir am grateful.

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HIV Virus? Seriously? When is the media going to try to understand what acronyms mean [shakes head]

Hello, My name daniel raso, i want to give praise to Dr abiola who helped me to cure my HIV/AID disease, please help me to give thanks to him, he is a great man who God send from heaven to save people’s life, this man also save the life of my people who have HIV/AID, please thank this man for me, also if you have any type of problem you can also contact him to help you out on it, he is a powerful man, contact him at deadly.diseases.cure@hotmail.com

..,

Hello, My name daniel raso, i want to give praise to Dr abiola who helped me to cure my HIV/AID disease, please help me to give thanks to him, he is a great man who God send from heaven to save people’s life, this man also save the life of my people who have HIV/AID, please thank this man for me, also if you have any type of problem you can also contact him to help you out on it, he is a powerful man, contact him at deadly.diseases.cure@hotmail.com

..,

This is great news! I've been living with HIV for 24 years now. I'm over it lol. Tired of getting sick and not being able to shake it off as easy as my non infected friends. This will be awesome. It'll also take away the stigma that happens when disclosure comes into play

Sending you love, brother!

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